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Abstract: A 6 page paper proposing specific research. One of the perplexing realities of the body of knowledge surrounding some of the paths of differentiation and affinities of specific molecules and specific genes is that they frequently behave in ways unexpected under current theory. Despite the fact that immunoglobulin (Ig) and T-cell receptor genes use the same recombinases, Ig genes are functionally rearranged only in B-cells and TCR genes only in T-cells. The basis for this lineage specificity of antigen receptor gene expression is still not well understood. The purpose of this proposed research is to attempt to determine why the genes are arranged only in the narrowly specified cell types. Bibliography lists 11 sources.
Catagory: Anatomy & Physiology